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Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
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[Ofatumumab - a new drug for the treatment of multiple sclerosis]

A N Boyko1,2, N F Smirnova1,2, I A Shchukin1,2

  • 1Pirogov Russian National Research Medical University, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|August 13, 2021
PubMed

Recently anti-B-cell therapy has been increasingly integrated into the treatment of multiple sclerosis (MS). This review is devoted to ofatumumab, a new drug of this line. Ofatumumab, an all-human monoclonal antibody used to treat chronic leukemia, binds to a different region than the binding site of other CD20 antibodies, including both a small and large loop in the CD20 receptor structure. This monoclonal antibody provides favorable results for MS by reducing the frequency of exacerbations and the risk of disability progression, significantly more pronounced when compared with teriflunomide. The drug can be used in patients with active relapsing MS and SPMS with exacerbations, with the ineffectiveness of first-line drugs as one of the options for second-line therapy, in patients with highly active MS, especially with a high risk of PML (transfer from natalizumab), as well as if there are difficulties in organizing intravenous courses in day hospitals (produced as outpatient injections).

Keywords:
anti-B-cell therapymultiple sclerosisofatamumabtreatment

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