miR-141-3p suppresses development of clear cell renal cell carcinoma by regulating NEK6

Yifei Liu1, Wenqiang Fu1, Feng Yin1

  • 1Department of Urology, Tangshan Central Hospital, Tangshan.

Anti-Cancer Drugs
|August 13, 2021
PubMed

Insights

MicroRNA-141-3p is downregulated in clear cell renal cell carcinoma (CCRCC) and inhibits tumor progression by targeting NEK6. Restoring miR-141-3p levels offers potential for CCRCC targeted therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Clear cell renal cell carcinoma (CCRCC) pathogenesis involves complex molecular mechanisms.
  • The role of microRNA-141-3p (miR-141-3p) in CCRCC development remains underexplored.
  • NIMA-related kinase-6 (NEK6) is implicated in various cancers.

Purpose of the Study:

  • To investigate the relationship between miR-141-3p and NEK6 in CCRCC.
  • To elucidate the functional role of the miR-141-3p/NEK6 interaction in CCRCC cell behavior.
  • To explore the therapeutic potential of targeting this pathway in CCRCC.

Main Methods:

  • Bioinformatic prediction (Starbase) and dual-luciferase reporter assay to confirm miR-141-3p targeting of NEK6.
  • Quantitative PCR and Western blot to assess miR-141-3p and NEK6 expression levels.
  • In vitro assays (Cell Counting Kit-8, Transwell, wound healing, flow cytometry) to evaluate cell proliferation, migration, invasion, and apoptosis.

Main Results:

  • miR-141-3p was significantly downregulated, while NEK6 was upregulated in CCRCC cells.
  • Overexpression of miR-141-3p suppressed CCRCC cell proliferation, migration, and invasion, while promoting apoptosis.
  • Upregulation of NEK6 partially reversed the inhibitory effects of miR-141-3p, confirming NEK6 as a direct target mediating these functions.
  • miR-141-3p regulates CCRCC progression by targeting NEK6.

Conclusions:

  • miR-141-3p acts as a tumor suppressor in CCRCC by inhibiting proliferation, migration, and invasion, and inducing apoptosis.
  • The miR-141-3p/NEK6 axis is a critical molecular mechanism in CCRCC development.
  • Targeting the miR-141-3p/NEK6 pathway represents a promising therapeutic strategy for CCRCC.

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