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Cardiac involvement in primary Sjӧgren's syndrome
Li Qin1, Yiwen Zhang1, Xiaoqian Yang1
1Department of Cardiology, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, No.82, Qinglong Street, Chengdu, Sichuan, China.
Rheumatology International
|August 13, 2021
Summary
Primary Sjögren's syndrome (pSS) significantly increases cardiovascular disease (CVD) risk, a leading cause of death. This review details CVD risk factors, symptoms, biomarkers, and treatments in pSS patients for better prognosis.
Area of Science:
- Rheumatology
- Cardiology
- Immunology
Background:
- Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease primarily affecting middle-aged women.
- Cardiac involvement is increasingly recognized in pSS, with cardiovascular disease (CVD) being a major cause of mortality.
- Understanding CVD in pSS is crucial for improving patient outcomes.
Purpose of the Study:
- To review cardiovascular risk factors in pSS patients.
- To outline clinical manifestations and biomarkers of cardiac involvement in pSS.
- To discuss therapeutic strategies for managing CVD in pSS.
Main Methods:
- Literature review of studies on cardiac involvement in primary Sjögren's syndrome.
- Analysis of cardiovascular risk factors, clinical presentations, biomarkers, and treatments.
- Synthesis of current knowledge on CVD in pSS.
Main Results:
- CVD risk in pSS is influenced by factors including age, hypertension, diabetes, dyslipidemia, and disease characteristics.
- Cardiac manifestations in pSS can be diverse and impact prognosis.
- Early detection and management of CVD are vital for pSS patients.
Conclusions:
- Cardiac involvement is a significant concern in primary Sjögren's syndrome, contributing to mortality.
- Comprehensive assessment of cardiovascular risk and tailored treatment strategies are essential for pSS patients.
- Further research into cardiac involvement in pSS is warranted.
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