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Related Experiment Video

Updated: Oct 24, 2025

Development of a Rabbit Chronic-Like Rotator Cuff Injury Model for Study of Fibrosis and Muscular Fatty Degeneration
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Polydeoxyribonucleotide and Polynucleotide Improve Tendon Healing and Decrease Fatty Degeneration in a Rat Cuff

Jung-Taek Hwang1, Sang-Soo Lee2, Sang Hak Han3

  • 1Department of Orthopedic Surgery, Chuncheon Sacred Heart Hospital, Hallym University Medical College, 77, Sakju-ro, Chuncheon-si, Gangwon-do, 24253, Republic of Korea. drakehjt@hanmail.net.

Tissue Engineering and Regenerative Medicine
|August 13, 2021
PubMed
Summary

Polydeoxyribonucleotide (PDRN) and polynucleotide (PN) show promise in enhancing rotator cuff tendon healing and reducing fatty degeneration after surgical repair. These findings suggest potential therapeutic benefits for improving outcomes in patients with chronic rotator cuff tears.

Keywords:
Chronic rotator cuff tearFatty degenerationPolydeoxyribonucleotidePolynucleotideRat modelTendon healing

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Area of Science:

  • Orthopedic Surgery
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Rotator cuff tear repair often results in poor tendon healing and significant fatty degeneration.
  • Chronic tears present a particular challenge for successful surgical outcomes.
  • Current treatments lack effective methods to promote healing and reverse degeneration.

Purpose of the Study:

  • To investigate the efficacy of polydeoxyribonucleotide (PDRN) and polynucleotide (PN) in promoting tendon healing.
  • To evaluate the potential of PDRN and PN in reversing fatty degeneration after rotator cuff repair.
  • To assess the effects of PDRN and PN on histological and biomechanical properties in a rat infraspinatus chronic tear model.

Main Methods:

  • Sixty rats underwent infraspinatus tendon detachment and subsequent repair, randomized into saline (SR), PDRN (PR), or PN (PNR) groups.
  • Histological analysis (CD68, CD168, collagen fiber alignment) was performed at 3 and 6 weeks post-repair.
  • Biomechanical testing (load-to-failure) was conducted at 6 weeks post-repair.

Main Results:

  • PDRN and PN groups exhibited increased CD168-positive cells at 3 weeks, indicating an inflammatory response.
  • At 6 weeks, PDRN and PN groups showed reduced CD68-positive cells (macrophages) and increased parallel collagen fiber alignment compared to saline.
  • Muscle cross-sectional area was larger in the PR group, and load-to-failure values trended higher in PR and PNR groups, though not significantly.

Conclusions:

  • PDRN and PN treatments may enhance tendon healing following surgical repair.
  • These agents show potential in mitigating fatty degeneration in chronic rotator cuff tears.
  • Further research is warranted to confirm the clinical applicability of PDRN and PN in rotator cuff repair.