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Updated: Oct 24, 2025
Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
Published on: September 20, 2024
Specific detection of memory T-cells in COVID-19 patients using standardized whole-blood Interferon gammarelease
William Mouton1,2,3, Christelle Compagnon1,3, Kahina Saker1
1Joint Research Unit Hospices Civils de Lyon-bioMérieux, Civils Hospices of Lyon, Pierre-Bénite, Lyon Sud Hospital, Lyon, France.
Antigen-specific T-cells are essential for protective immunity against SARS-CoV-2. We set up a semi-automated whole-blood Interferon-gamma release assay (WB IGRA) to monitor the T-cell response after stimulation with SARS-CoV-2 peptide pools. We report that the WB IGRA is complementary to serological assays to assess SARS-CoV-2 immunity.
Antigen-specific T-cells are essential for protective immunity against SARS-CoV-2. We set up a semi-automated whole-blood Interferon-gamma release assay (WB IGRA) to monitor the T-cell response after stimulation with SARS-CoV-2 peptide pools. We report that the WB IGRA is complementary to serological assays to assess SARS-CoV-2 immunity.
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