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Sestrins regulate muscle stem cell metabolic homeostasis

Benjamin A Yang1, Jesus Castor-Macias1, Paula Fraczek1

  • 1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Stem Cell Reports
|August 13, 2021
PubMed
Summary

Sestrins protect muscle stem cells (MuSCs) from aging by maintaining their quiescent state. Loss of Sestrins leads to premature stem cell activation and impaired muscle regeneration in aged mice.

Keywords:
RNA sequencingagingmTORC1metabolismoxidative stressreactive oxygen speciesregenerationsatellite cells

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