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High-dose intravenous vitamin C attenuates hyperinflammation in severe coronavirus disease 2019

Guozhi Xia1, Di Fan2, Yanru He1

  • 1Department of Cardiology, Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Province, China.

Nutrition (Burbank, Los Angeles County, Calif.)
|August 13, 2021
PubMed

Insights

High-dose intravenous vitamin C (HIVC) may reduce inflammation in severe COVID-19 patients. This study found HIVC therapy significantly lowered inflammatory markers, suggesting a potential benefit for hyperinflammation management.

Area of Science:

  • Critical care medicine
  • Infectious diseases
  • Nutritional science

Background:

  • Severe COVID-19 is frequently associated with dangerous hyperinflammation.
  • Managing inflammatory markers is crucial for patient outcomes.

Purpose of the Study:

  • To evaluate the clinical effectiveness of high-dose intravenous vitamin C (HIVC) in mitigating hyperinflammation among severe COVID-19 patients.

Main Methods:

  • Retrospective cohort study of hospitalized severe COVID-19 patients.
  • Analysis of demographic data, laboratory findings, and inflammatory markers (hs-CRP, IL-6, TNF-α).
  • Comparison of inflammatory marker levels before and after HIVC treatment.

Main Results:

  • A high prevalence of hyperinflammation was observed in the study cohort.
  • Patients receiving HIVC showed significant reductions in inflammatory markers compared to controls.
  • HIVC administration was independently associated with greater reductions in inflammatory marker levels.

Conclusions:

  • High-dose intravenous vitamin C demonstrates potential in attenuating hyperinflammation in severe COVID-19.
  • HIVC may be a beneficial adjunctive therapy for reducing inflammatory markers in critical COVID-19 cases.
Abstract

Keywords:
COVID-19InflammationSARS-CoV-2Vitamin C

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