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Updated: Oct 24, 2025

How to Obtain Reliable Visual Event-related Potentials in Newborns

How to Obtain Reliable Visual Event-related Potentials in Newborns

Published on: October 24, 2019

Giant pattern VEPs in children.

Dorothy A Thompson¹, Oliver R Marmoy¹, Katrina L Prise²

¹Clinical and Academic Department of Ophthalmology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK; Ulverscroft Vision Research Group, UCL Great Ormond Street Institute for Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society

|August 13, 2021

Summary

This summary is machine-generated.

Giant amplitude visual evoked potentials (VEPs) in children may indicate increased intracranial pressure (ICP). This study found 81% of children with giant VEPs had conditions risking raised ICP, suggesting VEPs as a potential diagnostic indicator.

Keywords:

Craniosynostosis Giant amplitude Intracranial hypertension Raised intracranial pressure VEP Visual evoked potential rICP

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Event-related Potentials During Target-response Tasks to Study Cognitive Processes of Upper Limb Use in Children with Unilateral Cerebral Palsy

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Published on: January 11, 2016

Area of Science:

Pediatric Ophthalmology
Neurophysiology
Pediatric Neurology

Background:

Giant amplitude pattern reversal visual evoked potentials (VEPs) are uncommon in children.
The clinical significance of these VEPs, particularly in relation to intracranial pressure, requires further elucidation.

Purpose of the Study:

To investigate the clinical significance of giant amplitude VEPs in pediatric patients.
To determine the association between giant VEPs and conditions associated with raised intracranial pressure (ICP).

Main Methods:

Retrospective analysis of 2750 pattern VEPs from children aged 16 and under.
Identification of 'giant' VEPs exceeding the 97.5th age-specific centile.
Correlation of giant VEP findings with clinical diagnoses, neuroimaging, and ICP measurements.

Main Results:

Twenty-seven children (median age 6 years) exhibited giant VEPs (P100 amplitude 65-163 µV).
81% (22/27) had conditions associated with a risk of raised ICP, including craniosynostosis and Idiopathic Intracranial Hypertension.
Structural findings included increased optic disc retinal thickness and neuro-radiological signs of CSF effacement.

Conclusions:

Sustained giant amplitude VEPs in children, especially at normal latency, warrant consideration for raised ICP.
VEPs may serve as a non-invasive indicator for further investigation of elevated intracranial pressure in pediatric populations.