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Phase-corrected buffer averaging for enhanced OCT angiography using FDML laser.

Yusi Miao, Mahsa Siadati, Jun Song

    Optics Letters
    |August 13, 2021
    PubMed
    Summary
    This summary is machine-generated.

    Ultrafast megahertz-rate optical coherence tomography angiography (OCTA) imaging is improved using a novel coherent buffer averaging technique. This method enhances OCTA contrast and phase alignment for faster, clearer retinal imaging.

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    Area of Science:

    • Ophthalmology
    • Biomedical Imaging
    • Optical Engineering

    Background:

    • Megahertz-rate optical coherence tomography angiography (OCTA) offers ultrafast clinical imaging potential.
    • High-speed OCTA systems face reduced sensitivity due to shot-noise limitations.
    • Improving OCTA contrast and speed is crucial for clinical applications.

    Purpose of the Study:

    • To present a coherent buffer averaging technique to enhance OCTA contrast.
    • To address sensitivity reduction in MHz-rate OCTA systems.
    • To improve retinal imaging speed and quality at 1060 nm.

    Main Methods:

    • Developed and applied a coherent buffer averaging technique with a Fourier-domain mode-locked (FDML) laser.
    • Characterized spectral variations among FDML buffers.
    • Implemented a numerical correction method for phase alignment.

    Main Results:

    • Achieved a 10-fold increase in phase alignment among buffers.
    • Demonstrated superior OCTA contrast compared to conventional multi-frame averaging.
    • Enabled faster acquisition times for retinal imaging.

    Conclusions:

    • Coherent buffer averaging significantly improves OCTA contrast in MHz-rate systems.
    • The technique overcomes sensitivity limitations in ultrafast OCTA.
    • This advancement facilitates higher quality and faster clinical retinal imaging.