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The Alarmone (p)ppGpp Regulates Primer Extension by Bacterial Primase

Christina N Giramma1, McKenna B DeFoer1, Jue D Wang1

  • 1Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.

Journal of Molecular Biology
|August 14, 2021
PubMed
Summary

The bacterial enzyme primase, crucial for DNA replication, is regulated by (p)ppGpp during starvation. This molecule inhibits primer extension and protects DNA replication fidelity under stress.

Keywords:
(p)ppGppbacterial primasegenome stabilityregulation of DNA replicationthe stringent response

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