Autoimmune atrophic gastritis in systemic sclerosis.

Area of Science:

• Gastroenterology
• Rheumatology
• Immunology

Background:

• Systemic sclerosis (SSc) is a rare autoimmune disease characterized by vascular dysfunction and immune system alterations.
• Gastrointestinal (GI) involvement is common in SSc, with esophageal and gastric issues frequently observed.
• Gastric antral vascular ectasia (GAVE) is a recognized gastric manifestation of SSc.

Observation:

• Autoimmune atrophic gastritis (AIG) is not typically associated with SSc.
• This case report details a unique patient with SSc presenting with both GAVE and AIG.
• A comprehensive literature review was performed to explore the potential link between AIG and SSc.

Findings:

• The coexistence of GAVE and AIG in a patient with SSc is a rare clinical finding.
• The literature review aimed to identify any previously documented associations between AIG and SSc.
• Understanding the underlying pathology of SSc-related GI manifestations is crucial.

Implications:

• This case suggests a potential, albeit rare, association between AIG and SSc.
• Further research is warranted to elucidate the pathogenetic mechanisms linking AIG and SSc.
• Recognizing this rare comorbidity can aid in the diagnosis and management of SSc patients with GI involvement.