Numerical simulation and analysis of effects of individual differences on the field distribution in the human brain...

The blood-brain barrier (BBB) opening induced by electromagnetic pulses (EMPs) may be a drug delivery strategy of central nervous system (CNS) diseases. However, the mechanism of EMP-induced BBB opening is still ambiguous. Previous studies have shown the relation between the external field and the extent of BBB permeation (referred to as the effect), while the connection between the internal field and the effect remains unknown. Here, the influence of individual differences on the field distribution in the human brain with EMPs is investigated, the dielectric parameters of the specific anthropomorphic mannequin (SAM) and structural parameters of the spherical brain are adjusted, and the field distribution in the brain illuminated by EMPs at the frequency range of 0-0.5 GHz is simulated based on the Computer Simulation Technology (CST) Studio Suite. The results show that the average electric field in the brain is about 1/100-1/5 of the incident field within the studied frequency range, individual differences have little effect on the field distribution in the human brain; and thus, it is reliable to establish the connection between the internal field and the effect, which is of great theoretical significance for further study of the mechanism of an EMP on the brain.