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Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course.

Camiel M van der Laan1,2, José J Morosoli-García3, Steve G A van de Weijer4

  • 1Biological Psychology, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands. C.M.vander.Laan@vu.nl.

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Summary
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Genetic influences on aggression in childhood persist throughout life. This study used polygenic scores (PGSs) and a novel

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Area of Science:

  • Behavioral genetics
  • Developmental psychology
  • Molecular genetics

Background:

  • Individual differences in aggression emerge early in life.
  • Understanding the genetic underpinnings of aggression across the lifespan is crucial.

Purpose of the Study:

  • To investigate whether genetic factors influencing childhood aggression also predict aggression throughout adulthood.
  • To examine the stability of genetic effects on aggression across different life stages.

Main Methods:

  • Utilized two large cohorts (Netherlands and Australia) with longitudinal aggression data.
  • Computed polygenic scores (PGSs) from genome-wide association studies of childhood/adolescent aggression.
  • Applied a novel 'rolling weights' mixed-effects model to assess age-dependent genetic effects.

Main Results:

  • Polygenic score effects on aggression remained relatively stable from adolescence to mid-adulthood in the Netherlands cohort.
  • A peak effect of polygenic scores on aggression was observed around age 40 in the Australian cohort.
  • Genetic influences on aggression present in early life appear to continue playing a role later in life.

Conclusions:

  • Genetic predispositions for aggression show some continuity across the human lifespan.
  • Molecular genetic findings provide evidence for the long-term influence of early-life genetic factors on aggressive behavior.
  • Further research is warranted to explore the developmental trajectories of genetic influences on aggression.