Related Experiment Video
Updated: Oct 24, 2025
Application of Mid-Pancreatectomy with End-to-End Anastomosis in Pancreatic Benign Tumors
Published on: February 9, 2024
Contemporary indications for upfront total pancreatectomy
Riccardo Casadei1,2, Claudio Ricci3,4, Carlo Ingaldi3,4
1Division of Pancreatic Surgery, IRCCS, Azienda Ospedaliero Universitaria di Bologna, Via Massarenti n.9, 40138, Bologna, Italy. riccardo.casadei@unibo.it.
Total pancreatectomy (TP) is a viable option for select patients in high-volume centers due to surgical advances. Improved perioperative care and modern treatments enhance short and long-term outcomes, justifying TP when indicated.
Area of Science:
- Surgical Oncology
- Gastroenterology
- Endocrinology
Background:
- Total pancreatectomy (TP) was historically feared due to poor outcomes.
- Advances in surgical techniques and perioperative care have improved TP results.
- Modern insulin and pancreatic enzyme preparations enhance patient quality of life post-TP.
Purpose of the Study:
- To review current indications for total pancreatectomy (TP).
- To evaluate upfront TP strategies.
- To consider surgical approach and vascular resection in TP indications.
Main Methods:
- Literature review of total pancreatectomy (TP) outcomes.
- Analysis of factors influencing TP success.
- Evaluation of patient selection criteria for TP.
Main Results:
- TP offers good short and long-term results in high-volume centers.
- Surgeon apprehension regarding TP is often unwarranted.
- TP is a viable option for selected patients.
Conclusions:
- Total pancreatectomy (TP) is a safe and effective procedure in experienced centers.
- Indications for TP should consider disease, surgical approach, and vascular involvement.
- TP can be a valuable treatment option for specific pancreatic conditions.
Related Concept Videos
01:29Chronic Pancreatitis II: Collaborative Care
Assessment:
01:30Acute Pancreatitis II: Clinical Manifestations and Management
01:27Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
01:24Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...