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Updated: Oct 24, 2025

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

There and back again: malaria parasite single-cell transcriptomics comes full circle.

Christopher Nötzel¹, Björn F C Kafsack²

¹Department of Microbiology and Immunology, Weill Cornell Medicine, New York, NY, USA; Biochemistry, Cell and Molecular Biology Graduate Program, Weill Cornell Medicine, New York, NY, USA.

Trends in Parasitology

|August 15, 2021

Summary

The Malaria Cell Atlas now includes Plasmodium falciparum transmission stages. This single-cell resolution resource maps gene expression across the entire malaria parasite life cycle for better understanding.

Keywords:

cell atlas malaria parasite scRNA-seq single-cell transcriptomics

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Published on: November 22, 2024

Area of Science:

Parasitology
Genomics
Cell Biology

Background:

The Malaria Cell Atlas (MCA) project aims to comprehensively map gene expression in the malaria parasite.
Understanding gene expression heterogeneity is crucial for targeting parasite development and transmission.

Purpose of the Study:

To complete the Malaria Cell Atlas by profiling the transmission stages of Plasmodium falciparum.
To provide a high-resolution, single-cell view of gene expression during parasite transmission.

Main Methods:

Single-cell RNA sequencing to analyze gene expression.
Bioinformatic analysis to map gene expression patterns across parasite life stages.

Main Results:

Detailed gene expression profiles for Plasmodium falciparum transmission stages are now available.
The study enhances the Malaria Cell Atlas with comprehensive coverage of the parasite's life cycle.

Conclusions:

The expanded Malaria Cell Atlas offers an invaluable, easy-to-use resource for malaria research.
This resource facilitates deeper insights into parasite biology, drug resistance, and transmission dynamics.