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Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
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PARkinson's: From cellular mechanisms to potential therapeutics

Zsofia Lengyel-Zhand1, Laura N Puentes2, Robert H Mach1

  • 1Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Pharmacology & Therapeutics
|August 15, 2021
PubMed
Summary

Poly (ADP-ribose) polymerase 1 (PARP-1) hyperactivation contributes to Parkinson's disease (PD) pathogenesis and neuronal loss. PARP-1 inhibitors show promise as disease-modifying therapeutics for PD.

Keywords:
PARP inhibitorPARP-1Parkinson's diseaseParthanatosPoly(ADP-ribose)

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