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Electric nerve stimulation for overactive bladder: an umbrella review
Min Li1, Ningning Zhang2, Di Wu1
1Invasive Technology Nursing Platform, The First Hospital of Jilin University.
Summary
Electrical nerve stimulation (ENS) shows potential for treating overactive bladder (OAB), with weak evidence of clinical efficacy and no reported side effects. Further high-quality research is needed to confirm ENS as a practical OAB treatment.
Area of Science:
- Urology
- Neurology
- Evidence Synthesis
Background:
- Overactive bladder (OAB) affects numerous individuals, with electrical nerve stimulation (ENS) being a proposed treatment.
- Existing systematic reviews on ENS for OAB present conflicting findings.
- A comprehensive evaluation of the existing evidence is necessary to clarify ENS effectiveness.
Purpose of the Study:
- To conduct an umbrella review summarizing evidence on the effectiveness and safety of ENS for OAB.
- To evaluate ENS for OAB using a rigorous methodology and multiple perspectives.
- To identify gaps in the current research landscape.
Main Methods:
- Systematic search of multiple databases (PubMed, EMBASE, Cochrane, Web of Science, CINAHL, PsycINFO, CNKI, CBM) up to February 2021.
- Inclusion of ten systematic reviews and meta-analyses encompassing 89 RCTs and 16 cohort studies (5004 participants).
- Quality assessment using AMSTAR 2.0 and estimation of summary effect sizes, confidence intervals, prediction intervals, and heterogeneity.
Main Results:
- Electrical nerve stimulation (ENS) appears to be effective and safe for overactive bladder (OAB).
- Analysis revealed weak evidence supporting the clinical efficacy of ENS for OAB.
- No significant side effects associated with ENS treatment for OAB were identified in the reviewed studies.
Conclusions:
- ENS demonstrates potential as a treatment for overactive bladder (OAB) with a favorable safety profile.
- Current evidence for clinical efficacy is limited, necessitating further investigation.
- High-quality research is crucial to establish ENS as a recommended, practical therapeutic option for OAB.
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