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Updated: Oct 24, 2025

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Resting-State Correlations of Fatigue Following Military Deployment

Jeffrey D Lewis1, Kristine M Knutson1, Stephen J Gotts1

  • 1Mental Health Clinic, Wright Patterson Medical Center, Wright Patterson Air Force Base, Ohio (Lewis); Behavioral Neurology Unit, National Institute of Neurological Disorders and Stroke, Bethesda, Md. (Knutson, Tierney, Wassermann); National Institute of Mental Health, Bethesda, Md. (Gotts); Department of Communication Science and Disorders, University of New Hampshire, Durham (Ramage, Robin); Department of Neurology, University of Utah School of Medicine, Salt Lake City (Tate); and Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor (Clauw, Williams).

The Journal of Neuropsychiatry and Clinical Neurosciences
|August 16, 2021
PubMed
Summary

Persistent mental fatigue in military servicemembers after deployment, particularly those with mild traumatic brain injury (mTBI), may stem from altered brain connectivity. This study found links between fatigue and striatal-prefrontal pathways.

Keywords:
Mental FatigueTraumatic Brain Injury

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