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Author Spotlight: Advancements in Understanding and Combatting Shigella Infections
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Author Spotlight: Advancements in Understanding and Combatting Shigella Infections

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Shigella sonnei, an emerging multidrug-resistant sexually transmitted pathogen in Franche-Comté, France

Souheil Zayet1, Timothée Klopfenstein1, Alix Pierron1

  • 1Department of Infectious Disease, Nord Franche-Comté Hospital, Trevenans, France.

Emerging Microbes & Infections
|August 16, 2021
PubMed

Insights

Multidrug-resistant Shigella sonnei infections are emerging among men who have sex with men (MSM). These infections, linked to specific sexual behaviors, require prompt laboratory confirmation and appropriate antibiotic treatment.

Area of Science:

  • Infectious Diseases
  • Public Health
  • Microbiology

Background:

  • Shigella sonnei (S. sonnei) can be sexually transmitted, posing a risk to men who have sex with men (MSM) due to distinct sexual behaviors.
  • Emerging cases of multidrug-resistant S. sonnei infections have been observed in MSM populations.

Discussion:

  • Three cases of multidrug-resistant S. sonnei in MSM are presented, including one HIV-infected individual and two on HIV pre-exposure prophylaxis.
  • S. sonnei isolates were resistant to azithromycin but treatable with parenteral third-generation cephalosporins.
  • Epidemiological linkage was identified between two of the three cases.

Key Insights:

  • Highlights the emergence of multidrug-resistant S. sonnei in MSM.
  • Underscores the association between S. sonnei infections and specific sexual behaviors within this demographic.
  • Demonstrates successful treatment outcomes with third-generation cephalosporins.

Outlook:

  • Further surveillance is needed to monitor the prevalence and transmission patterns of multidrug-resistant S. sonnei among MSM.
  • Understanding sexual transmission dynamics is crucial for targeted prevention strategies.
  • Continued research into antimicrobial resistance patterns of S. sonnei is essential for effective public health interventions.
Keywords:
Shigella sonneimultidrug-resistantsexually transmitted infectionsshigellosisthird-generation cephalosporins

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