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Updated: Oct 24, 2025

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
09:05

Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation

Published on: October 20, 2016

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Myocardial involvement in Behçet's disease may be higher in patients with Neuro-Behçet's disease: a speckle tracking

Murat Sunbul1, Ipek Gursoy Midi2, Seda Kutlug Agackiran3

  • 1Department of Cardiology, Marmara University School of Medicine, Istanbul, Turkey.

Acta Cardiologica
|August 16, 2021
PubMed

Insights

Neuro-Behcet's disease (NBD) is linked to subclinical myocardial dysfunction, showing reduced left ventricular global longitudinal strain (LV-GLS) and atrial conduit strain. NBD independently predicts impaired LV-GLS in Behcet's disease patients.

Area of Science:

  • Cardiology
  • Neurology
  • Rheumatology

Background:

  • Behcet's disease (BD) can cause severe neurological and cardiovascular complications.
  • Neuro-Behcet's disease (NBD) significantly contributes to BD morbidity and mortality.
  • Subclinical myocardial dysfunction in NBD requires further investigation.

Purpose of the Study:

  • To compare subclinical myocardial dysfunction in NBD patients versus BD patients with other manifestations.
  • To identify cardiac function differences between NBD and non-neurologic BD patients.

Main Methods:

  • Transthoracic echocardiography with 2D speckle tracking echocardiography (STE) was performed.
  • Evaluated left ventricular (LV) and left atrial (LA) functions in 40 NBD patients, 40 BD patients, and 40 controls.
  • Assessed LV global longitudinal strain (LV-GLS) and LA conduit strain.

Main Results:

  • LV-GLS was significantly lower in NBD and non-neurologic BD patients compared to controls.
  • LA conduit strain was reduced in NBD patients versus controls.
  • NBD was identified as an independent predictor of reduced LV-GLS.

Conclusions:

  • Behcet's disease is associated with impaired LV and LA function.
  • NBD patients exhibit lower LV-GLS and LA conduit strain.
  • Neurological involvement in BD is linked to cardiac dysfunction.
Abstract

Keywords:
Behcet’s diseaseNeuro-Behcet’s diseasecardiac involvementspeckle tracking echocardiography

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