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Updated: Oct 24, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Optimizing prognosis in atrial fibrillation: A call to action in Portugal
Jorge Ferreira1, Natália António2, Nuno Cortez-Dias3
1Serviço de Cardiologia, Hospital de Santa Cruz, Centro Hospitalar de Lisboa Ocidental, Carnaxide, Portugal.
Insights
Atrial fibrillation (AF) management has advanced with new anticoagulants, yet residual risks like stroke and bleeding persist. Early detection and comprehensive strategies are crucial for improving patient outcomes and prognosis.
Area of Science:
- Cardiology
- Thrombocardiology
- Public Health
Background:
- Atrial fibrillation (AF) is the most prevalent arrhythmia globally, causing significant cardiovascular mortality, morbidity, and economic burden.
- Oral anticoagulation (OAC) is vital for stroke prevention in AF patients.
- Non-vitamin K oral anticoagulants (NOACs) have revolutionized thrombocardiology, but residual vascular risks remain.
Purpose of the Study:
- To review current epidemiological data on atrial fibrillation.
- To discuss advancements in early AF detection and rhythm control strategies.
- To explore optimal management of OAC, bleeding, and future prognostic improvements.
Main Methods:
- Literature review of epidemiological data on AF.
- Analysis of current tools for early AF detection.
- Evaluation of catheter ablation for rhythm control.
- Assessment of periprocedural OAC and bleeding management.
Main Results:
- Significant residual vascular risks persist despite advances in AF treatment.
- Silent AF, bleeding complications, sudden death, and heart failure are key concerns.
- New tools and strategies are needed to mitigate these residual risks.
Conclusions:
- Comprehensive management strategies are essential for improving AF prognosis.
- Early detection, optimized anticoagulation, and risk factor management are critical.
- Further research is needed to address residual risks and enhance patient outcomes.
Abstract:
Atrial fibrillation (AF), the most common arrhythmia in the adult population worldwide, represents a significant burden in terms of cardiovascular mortality and morbidity and has repercussions on health economics. Oral anticoagulation (OAC) is key to stroke prevention in AF and, in recent years, results from landmark clinical trials of non-vitamin K oral anticoagulants (NOAC) have triggered a paradigm shift in thrombocardiology. Despite these advances, there is still a significant residual vascular risk associated with silent AF, bleeding, premature sudden death and heart failure. The authors review AF epidemiologic data, the importance of new tools for early AF detection, the current role of catheter ablation for rhythm control in AF, the state-of-the-art in periprocedural OAC, the optimal management of major bleeding, the causes of residual premature death and future strategies for improvements in AF prognosis.
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