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Cadmium and cardiovascular disease: An overview of pathophysiology, epidemiology, therapy, and predictive value
Hung-Chen Lin1, Wei-Ming Hao2, Pao-Hsien Chu3
1Department of Cardiology, Huashan Hospital of Fudan University, Shanghai, China; Shanghai Medical College, Fudan University, Shanghai, China.
Insights
This review explores the toxic heavy metal cadmium and its link to cardiovascular disease. Further research is needed to understand cadmium
Area of Science:
- Environmental toxicology
- Cardiovascular medicine
- Public health
Background:
- Cadmium is a toxic heavy metal linked to numerous diseases.
- Cadmium's cardiovascular effects are not fully understood.
- Cadmium shows predictive value for mortality in cardiovascular disease patients.
Purpose of the Study:
- To review the role of cadmium in cardiovascular disease.
- To highlight the need for further research on cadmium and cardiovascular mortality.
Main Methods:
- Literature review of existing studies on cadmium and cardiovascular disease.
Main Results:
- Cadmium exposure is associated with various health issues.
- Mechanisms of cadmium's cardiovascular impact require elucidation.
- Cadmium levels predict mortality in heart conditions.
Conclusions:
- Cadmium's role in cardiovascular disease warrants more investigation.
- Understanding cadmium's impact is crucial for public health and patient outcomes.
Abstract:
Cadmium is a widely distributed toxic heavy metal that has been associated with many diseases including chronic renal dysfunction, osteomalacia, acute heart failure, secondary hypertension, and atherosclerosis. Although several studies have suggested that cadmium may affect multiple systems by inducing lipid per oxidation in cells and disturbing the antioxidant system, the mechanism by which cadmium affects the cardiovascular system remains unclear. Recent studies on heart failure and acute myocardial infarction have shown that cadmium has good predictive ability for mortality in patients with cardiovascular disease. In this study, we briefly review the role of cadmium in cardiovascular disease, which may prompt further studies to investigate the potential association between cadmium and mortality in patients with cardiovascular disease.
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