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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
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Related Experiment Video

Updated: Oct 24, 2025

Multi-modal Imaging of Angiogenesis in a Nude Rat Model of Breast Cancer Bone Metastasis Using Magnetic Resonance Imaging, Volumetric Computed Tomography and Ultrasound
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PET Imaging for Breast Cancer.

Amy M Fowler1, Steve Y Cho2

  • 1Breast Imaging and Intervention Section, Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-3252, USA; Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI 53705, USA; University of Wisconsin Carbone Cancer Center, 600 Highland Avenue, Madison, WI 53792, USA.

Radiologic Clinics of North America
|August 16, 2021
PubMed
Summary

This review explores positron emission tomography (PET) imaging for breast cancer. It covers 2-deoxy-2-[18F]fluoro-d-glucose (FDG) PET/CT, PET/MRI, and new estrogen receptor imaging with 16α-[18F]fluoroestradiol (FES).

Keywords:
(18)F-FDG(18)F-FESBreast cancerComputed tomographyMagnetic resonance imagingPositron emission tomography

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Area of Science:

  • Oncology
  • Radiology
  • Nuclear Medicine

Background:

  • Imaging is crucial for breast cancer patient management.
  • Positron emission tomography (PET) offers advanced diagnostic capabilities.

Purpose of the Study:

  • To review the role of PET imaging in breast cancer diagnosis and management.
  • To highlight current and emerging PET radiopharmaceuticals and techniques.

Main Methods:

  • Review of clinical indications and limitations of FDG PET/CT.
  • Discussion of the potential applications of PET/MRI.
  • Overview of 16α-[18F]fluoroestradiol (FES) PET for estrogen receptor imaging.

Main Results:

  • FDG PET/CT has established clinical uses but also limitations in breast cancer.
  • PET/MRI presents potential advantages for combined anatomical and functional imaging.
  • FES PET is a newly approved tool for visualizing estrogen receptor status.

Conclusions:

  • PET imaging, including FDG PET/CT, PET/MRI, and FES PET, plays a significant role in breast cancer care.
  • Emerging techniques like FES PET expand diagnostic options for receptor-targeted imaging.
  • Further research will likely refine the utility of various PET modalities in breast cancer management.