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[The impact of COVID-19 in patients with severe aortic stenosis: Artificial intelligence research]
Virginia Pascual-Tejerina1, Pedro Beneyto2, Tomás Cantón1
1Servicio de Cardiología, Hospital Virgen de la Salud, Toledo, España.
Insights
The COVID-19 pandemic increased mortality for severe aortic stenosis patients. Both COVID-19 positive and negative patients experienced higher death rates during the pandemic compared to pre-COVID times.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Context:
- Severe aortic stenosis carries a high mortality risk without intervention.
- The COVID-19 pandemic significantly disrupted healthcare access and patient flow.
- Understanding the pandemic's impact on cardiovascular disease outcomes is crucial.
Purpose:
- To assess the effect of the COVID-19 pandemic's first wave on mortality in severe aortic stenosis patients.
- To compare mortality rates during the pandemic with the same period in the previous year.
- To analyze mortality differences between COVID-19 positive and negative patients with severe aortic stenosis.
Summary:
- A Spanish region observed a 13.82% decrease in hospital admissions during the pandemic's first wave.
- Among 1,112 patients with severe aortic stenosis, 5.48% tested positive for COVID-19.
- Mortality rates were significantly higher in the pandemic period for both COVID-19 negative (4.37% vs. 2.57%) and positive (11.47%) patients compared to pre-COVID eras.
Impact:
- The study highlights an excess mortality in severe aortic stenosis patients during the pandemic, irrespective of COVID-19 status.
- Cardiac surgeries showed a decreasing trend, with a significant reduction in COVID-19 positive patients.
- Findings underscore the pandemic's adverse effect on outcomes for vulnerable cardiovascular patient populations.
Introduction:
Untreated, severe, symptomatic aortic stenosis is associated with an ominous diagnosis without intervention. This study aims to determine the impact of the COVID-19 pandemic on the mortality of patients with severe stenosis during the first wave and compare it with the same period last year.
Methods:
All patients who went to the hospitals in an Spanish region during the first wave, and in the same period of previous year, were analyzed using artificial intelligence-based software, evaluating the mortality of patients with severe aortic stenosis with and without COVID-19 during the pandemic and the pre-COVID era. Mortality of the 3 groups was compared. Regarding cardiac surgeries was a tendency to decrease (P = .07) in patients without COVID-19 between the pandemic and the previous period was observed. A significant decrease of surgeries between patients with COVID-19 and without COVID-19 was shown.
Results:
Data showed 13.82% less admitted patients during the first wave. A total of 1,112 of them had aortic stenosis and 5.48% were COVID-19 positive. Mortality was higher (P = .01), in COVID-19 negative during the pandemic (4.37%) versus those in the pre-COVID-19 era (2.57%); it was also in the COVID-19 positive group (11.47%), versus COVID-19 negative (4.37%) during the first wave (P = .01).
Conclusions:
The study revealed a decrease in patients who went to the hospital and an excess of mortality in patients with severe aortic stenosis without infection during the first wave, compared to the same period last year; and also, in COVID-19 positive patients versus COVID-19 negative.
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