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Related Experiment Video

Updated: Oct 24, 2025

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Semantic Memory and Lexical Availability in Parkinson's Disease: A Statistical Learning Study.

Juan F Cardona1,2, Johan S Grisales-Cardenas1,2, Catalina Trujillo-Llano1,2

  • 1Facultad de Psicología, Universidad del Valle, Santiago de Cali, Colombia.

Frontiers in Aging Neuroscience
|August 16, 2021
PubMed
Summary
This summary is machine-generated.

Parkinson's disease (PD) patients show deficits in semantic memory (SM) and lexical availability (LA), particularly with non-living items. These cognitive impairments, especially in naming non-living things, can help classify PD groups.

Keywords:
Parkinson’s diseaseembodied cognitionlexical availabilitysemantic memoryverbal fluency

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Area of Science:

  • Neuroscience
  • Cognitive Psychology

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder affecting motor and cognitive functions.
  • Semantic fluency deficits are known in PD, but specific semantic memory (SM) and lexical availability (LA) have not been fully explored.

Purpose of the Study:

  • To characterize cognitive performance in SM and LA in early-stage PD patients.
  • To identify key neuropsychological variables for classifying PD groups.

Main Methods:

  • Thirty early-stage PD patients and 30 controls were assessed.
  • Cognitive performance evaluated using general cognitive tests, SM tasks (living/non-living naming), and LA measures.

Main Results:

  • PD patients performed significantly lower than controls in SM tasks, especially naming non-living items.
  • PD patients exhibited reduced word recall in LA tasks, indicating poorer recall strategies.
  • Classification algorithms showed high accuracy (∼80%) for SM tasks, particularly naming non-living things.

Conclusions:

  • Frontostriatal degeneration in PD impacts semantic categorization and search strategies.
  • SM, especially non-living item denomination, is a sensitive marker for PD classification.
  • Findings support the embodied view of cognition in the context of PD.