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Immune Equilibrium Depends on the Interaction Between Recognition and Presentation Landscapes
Daniil Shevyrev1, Valeriy Tereshchenko2, Vladimir Kozlov1
1Laboratory of Clinical Immunopathology, Research Institute for Fundamental and Clinical Immunology, Novosibirsk, Russia.
Frontiers in Immunology
|August 16, 2021
Summary
Immune system balance relies on antigen recognition and presentation. Changes in these landscapes, influenced by genetics and cell dynamics, can increase risks for cancer, autoimmune diseases, and infections.
Area of Science:
- Immunology
- Bioinformatics
- Genetics
Background:
- Modern immunology examines B and T cell antigen-recognizing repertoires.
- Understanding clonal diversity and its formation is crucial for immune function.
Purpose of the Study:
- To review the structure and organization of antigen-recognizing repertoires.
- To summarize advances in bioinformatics analysis of T and B cell sequencing data.
- To present contemporary ideas on clonal diversity mechanisms.
Main Methods:
- Review of current literature on immunology and bioinformatics.
- Analysis of sequencing data from T and B cell repertoires.
- Focus on HLA gene allelic variants and antigen presentation spectra.
Main Results:
- Immune equilibrium depends on the interplay between antigen recognition and presentation landscapes.
- Life-long changes in these landscapes can affect adaptive immunity's protective function.
- Mechanisms include cell trans-differentiation, homeostatic proliferation, aging, and antigen presentation alterations.
Conclusions:
- Alterations in immune landscapes may increase the risk of oncological and autoimmune diseases.
- These changes can also influence susceptibility to infectious agents.
- Maintaining immune homeostasis is vital for overall health and disease prevention.
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