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Association of ERCC gene polymorphism with osteosarcoma risk
Guanliang Wang1, Jianping Li1, Xiling Xu2
1Department of TCM, Army 75th Group Military Hospital of People's Liberation Army, Dali 671000, China.
African Health Sciences
|August 16, 2021
Summary
This meta-analysis found that ERCC gene polymorphisms are not linked to osteosarcoma risk. However, specific ERCC2 (Excision Repair Cross-Complementation group 2) gene variants were associated with overall survival in osteosarcoma patients.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Conflicting evidence exists regarding the association between ERCC gene polymorphisms and osteosarcoma risk and overall survival.
- A comprehensive meta-analysis is needed to clarify these relationships.
Purpose of the Study:
- To assess the association between ERCC gene polymorphisms and the risk of developing osteosarcoma.
- To evaluate the relationship between ERCC gene polymorphisms and the overall survival of osteosarcoma patients.
Main Methods:
- Systematic literature search of association studies in PubMed.
- Inclusion of eligible reports for meta-analysis.
- Calculation of pooled estimates to determine associations.
Main Results:
- Four studies analyzed ERCC gene polymorphism and osteosarcoma risk; nine studies examined ERCC gene polymorphism and osteosarcoma overall survival.
- No significant association was found between several ERCC1 and ERCC2 polymorphisms and osteosarcoma risk.
- Similarly, most analyzed ERCC1 and ERCC2 polymorphisms showed no association with osteosarcoma overall survival.
- Notably, the ERCC2 rs13181 A allele and GG genotype were significantly associated with improved overall survival in osteosarcoma.
Conclusions:
- The ERCC2 rs13181 A allele and GG genotype are associated with overall survival in osteosarcoma patients.
- Further research may elucidate the precise mechanisms underlying this association.
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