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Related Experiment Videos

Quantitative toxicology: interlaboratory and intermethod evaluation in New York State.

S N Buhl, P Kowalski, R E Vanderlinde

    Clinical Chemistry
    |March 1, 1978
    PubMed
    Summary

    New York

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    Area of Science:

    • Clinical Toxicology
    • Laboratory Medicine

    Background:

    • The New York State Department of Health initiated a proficiency testing program for quantitative toxicology in 1974.
    • The program assesses laboratory performance using serum samples with specific drugs.

    Purpose of the Study:

    • To evaluate and improve the accuracy of quantitative drug measurements in clinical laboratories.
    • To address challenges in achieving uniform accuracy due to a lack of adequate calibration materials.

    Main Methods:

    • Quarterly distribution of serum samples containing barbiturate and phenytoin, plus glutethimide, procainamide, or theophylline.
    • Development of a method using pure drugs weighed into a bovine serum matrix, with target values confirmed by reference laboratories.

    Main Results:

    • Laboratory proficiency in quantitating test samples increased from 25% (1974-1975) to 40% (1975-1976).
    • Improvements attributed to licensure, technology, and quality control practices.
    • Method comparisons for barbiturate and phenytoin yielded unique equations.

    Conclusions:

    • Proficiency testing programs can drive improvements in laboratory accuracy.
    • Establishing reliable calibration materials is crucial for consistent toxicological analysis.
    • Further research is needed to understand variations in analytical methods.

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