Related Experiment Video
Updated: Oct 24, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Endoplasmic Reticulum Stress in Diabetic Nephrology: Regulation, Pathological Role, and Therapeutic Potential
Lihua Ni1, Cheng Yuan2, Xiaoyan Wu1
1Department of Nephrology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Abstract:
Recent progress has been made in understanding the roles and mechanisms of endoplasmic reticulum (ER) stress in the development and pathogenesis of diabetic nephropathy (DN). Hyperglycemia induces ER stress and apoptosis in renal cells. The induction of ER stress can be cytoprotective or cytotoxic. Experimental treatment of animals with ER stress inhibitors alleviated renal damage. Considering these findings, the normalization of ER stress by pharmacological agents is a promising approach to prevent or arrest DN progression. The current article reviews the mechanisms, roles, and therapeutic aspects of these findings.
Related Concept Videos
Role of ER in the Secretory Pathway
Components of the secretory pathway
About a third of proteins synthesized in the cell are sorted via the secretory route. They shuffle between different compartments in membrane-bound vesicles until they reach their final destination. The main intracellular compartments involved...
Nephrotic Syndrome III : Nursing Management
Regulation of the Unfolded Protein Response
Chronic Kidney Disease III: Interprofessional Care
Nephrotic Syndrome II : Assessment and Medical Management
Chronic Kidney Disease I: Introduction

