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Related Experiment Video

Updated: Oct 24, 2025

Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
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Recent Progress on NIR-II Photothermal Therapy.

Yunguang Zhang1, Siyu Zhang1, Zihan Zhang1

  • 1School of Science, Xi'an University of Posts and Telecommunications, Xi'an, China.

Frontiers in Chemistry
|August 16, 2021
PubMed
Summary
This summary is machine-generated.

Photothermal therapy using near-infrared II (NIR-II) light offers deeper tumor penetration than NIR-I. This review explores NIR-II photothermal nanomaterials for enhanced cancer treatment and nanomedicine applications.

Keywords:
NIR-IIcancer therapynanomaterialsphotothermal conversionphotothermal therapy

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Area of Science:

  • Nanomedicine
  • Biomedical Engineering
  • Oncology

Background:

  • Photothermal therapy (PTT) is a promising cancer treatment.
  • Near-infrared I (NIR-I) light (750-900 nm) offers good biological penetration but limited depth for solid tumors.
  • Near-infrared II (NIR-II) light (1000-1700 nm) provides deeper penetration, higher radiation tolerance, and greater potential for photothermal conversion.

Purpose of the Study:

  • To review photothermal properties of materials in the NIR-II region.
  • To explore the application prospects of NIR-II photothermal nanomaterials in cancer therapy.
  • To highlight advancements in nanomedicine for cancer treatment.

Main Methods:

  • Literature review of photothermal nanomaterials.
  • Analysis of materials including gold (Au) nanomaterials, 2D materials, metal oxide sulfides, and polymers.
  • Evaluation of photothermal conversion efficiency and biological penetration in the NIR-II window.

Main Results:

  • NIR-II light enables significantly deeper tissue penetration compared to NIR-I.
  • Various nanomaterials (Au, 2D materials, metal oxides, polymers) exhibit promising photothermal properties in the NIR-II region.
  • These materials demonstrate potential for enhanced photothermal conversion and therapeutic efficacy in solid tumors.

Conclusions:

  • NIR-II photothermal nanomaterials represent a significant advancement for cancer therapy.
  • Deeper light penetration of NIR-II is crucial for treating solid tumors effectively.
  • This review provides insights for future research in nanomedicine and cancer treatment.