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Updated: Oct 24, 2025

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Basic Research on Tendon Repair: Strategies, Evaluation, and Development.

Zhi Jie Li1,2, Qian Qian Yang1,2, You Lang Zhou1,2

  • 1Research for Frontier Medicine and Hand Surgery Research Center, The Nanomedicine Research Laboratory, Research Center of Clinical Medicine, Department of Hand Surgery, Affiliated Hospital of Nantong University, Nantong, China.

Frontiers in Medicine
|August 16, 2021
PubMed
Summary
This summary is machine-generated.

Tendon injuries cause pain and function loss, with complex natural healing and high re-tear rates. Recent advances in gene therapy, stem cell therapy, and Platelet-rich plasma (PRP) therapy offer new hope for effective tendon healing treatments.

Keywords:
gene therapygrowth factor and drug therapyplatelet-rich plasma therapystem cell therapytendontendon healingtendon injurytissue engineering

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Orthopedics

Background:

  • Tendon injuries, both chronic and acute, result in significant pain and functional impairment.
  • The natural tendon healing process is intricate, involving wound healing, proliferation, and remodeling, and is often complicated by a high re-tear rate.
  • Effective management of tendon injuries remains a critical clinical challenge.

Purpose of the Study:

  • To review the current understanding of tendon injury.
  • To summarize recent advancements in tendon healing strategies.
  • To explore novel therapeutic approaches for improving tendon repair and regeneration.

Main Methods:

  • Literature review of recent research on tendon healing.
  • Analysis of emerging therapeutic modalities including gene therapy, stem cell therapy, Platelet-rich plasma (PRP) therapy, growth factor and drug therapy, and tissue engineering.
  • Synthesis of current knowledge on the biological processes involved in tendon repair.

Main Results:

  • Tendon healing involves a complex, multi-stage process with inherent challenges like re-tear.
  • Several innovative therapies are under investigation to enhance tendon healing.
  • These include gene therapy, stem cell therapy, PRP therapy, growth factors, drug interventions, and tissue engineering.

Conclusions:

  • Despite promising research, most advanced tendon healing therapies are not yet clinically mature.
  • Continued research and optimization are crucial for translating these innovations into effective clinical applications.
  • The future holds significant potential for improved management of tendon injuries through these novel approaches.