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The Association Between Left Ventricular Hypertrophy and the Occurrence and Prognosis of Atrial Fibrillation: A

Huaqiang Xiang1, Yangjing Xue1, Zhi Chen2

  • 1Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.

Frontiers in Cardiovascular Medicine
|August 16, 2021
PubMed

Insights

Left ventricular hypertrophy (LVH) significantly increases the risk of developing atrial fibrillation (AF). LVH also worsens outcomes for AF patients, including mortality and recurrence after treatment.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Clinical Research

Background:

  • Left ventricular hypertrophy (LVH) is a common cardiac condition.
  • Atrial fibrillation (AF) is a prevalent arrhythmia with significant morbidity.
  • The relationship between LVH and AF, particularly its prognostic implications, requires further clarification.

Approach:

  • A comprehensive meta-analysis was conducted.
  • Searched major medical databases (Medline, Embase, Cochrane Library) through April 2020.
  • Included 16 cohorts comprising 133,091 individuals to assess the association between LVH and AF.

Key Points:

  • Individuals with LVH exhibit a 46% higher susceptibility to developing AF compared to those without LVH.
  • In patients with both AF and LVH, the risk of all-cause mortality is 60% higher.
  • LVH is associated with a 45% increased likelihood of AF progression and a 58% higher recurrence rate post-catheter ablation.

Conclusions:

  • LVH is a strong independent predictor of AF development.
  • LVH portends a poorer prognosis in patients diagnosed with AF.
  • Managing LVH may be crucial for improving outcomes in AF patients.

Keywords:
atrial fibrillationelectrocardiogramleft ventricular hypertrophypredictorprognosis

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