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Updated: Oct 24, 2025

Intravitreous Injection for Establishing Ocular Diseases Model

Intravitreous Injection for Establishing Ocular Diseases Model

Published on: October 1, 2007

Embryonic Intravitreous Injection in Mouse.

Liyuan Cui¹, Yupu Diao¹, Jiayi Zhang¹

¹State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University, Shanghai, China.

|August 16, 2021

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Researchers developed a new method to visualize retinal axons in mouse embryos. This technique allows for the study of early visual circuit wiring in the developing brain.

Area of Science:

Neuroscience
Developmental Biology
Visual System Research

Background:

Retinal ganglion cell (RGC) axons transmit visual information from the retina to key brain nuclei like the lateral geniculate nucleus (LGN) and superior colliculus (SC).
The precise wiring of these retinal projections is established before the onset of vision.
Studying embryonic retinal axons is challenging due to technical difficulties.

Purpose of the Study:

To overcome technical challenges in visualizing early retinal projections.
To enable the study of the formation of visual circuits during embryonic development.
To provide a method for investigating the wiring of retinal axons in mouse embryos.

Main Methods:

Development of a novel technique for embryonic intravitreous injection of dyes in mice.

Keywords:

Embryo Intravitreous injection Retinal axons Retinal projection Uterus

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Last Updated: Oct 24, 2025

Intravitreous Injection for Establishing Ocular Diseases Model

Intravitreous Injection for Establishing Ocular Diseases Model

Published on: October 1, 2007

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Intravenous and Intra-amniotic In Utero Transplantation in the Murine Model

Published on: October 9, 2018

Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye

Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye

Published on: November 25, 2012

Visualization of retinal projections to the LGN and SC in mouse embryos.

Main Results:

Successful visualization of retinal ganglion cell axons projecting to the LGN and SC in embryonic mice.
Demonstration of a feasible method for studying early visual pathway development.

Conclusions:

The developed method facilitates the study of early visual circuit wiring in mouse embryos.
This technique opens new avenues for understanding the developmental processes underlying vision.
Further research can now explore the intricacies of retinal axon guidance and target selection during embryogenesis.