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Related Concept Videos

Imaging Studies for Cardiovascular System IV: CMRI01:21

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Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Imaging Studies for Cardiovascular System III: X-Ray01:20

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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
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DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
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Strain Imaging in Cardio-Oncology.

Jennifer E Liu1,2, Ana Barac3, Paaladinesh Thavendiranathan4

  • 1Cardiology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

JACC. Cardiooncology
|August 16, 2021
PubMed
Summary

Global longitudinal strain (GLS) offers a sensitive method for detecting early cardiotoxicity during cancer therapy. This primer guides clinicians on acquiring and interpreting GLS for improved patient management in cardio-oncology.

Keywords:
2D, 2-dimensional3D, 3-dimensionalACC, American College of CardiologyAL, amyloid light chainsASE, American Society of EchocardiographyCMRI, cardiac magnetic resonance imagingCTRCD, cancer treatment–related cardiac dysfunctionDICOM, Digital Imaging and Communications in MedicineEACVI, European Association of Cardiovascular ImagingGLS, global longitudinal strainLV, left ventricleLVEF, left ventricular ejection fractionROI, region of interestSTE, speckle tracking echocardiographyVEGF, vascular endothelium growth factorcancercardiotoxicityechocardiographyglobal longitudinal strainleft ventricular function

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Area of Science:

  • Cardiology
  • Oncology
  • Medical Imaging

Background:

  • Echocardiography is vital for managing cardiotoxicity in cancer patients.
  • Left ventricular ejection fraction (LVEF) is commonly used but lacks sensitivity for early detection of cardiac dysfunction.
  • Subclinical cardiac changes from cardiotoxic treatments require more sensitive monitoring methods.

Purpose of the Study:

  • To provide a primer on acquiring and interpreting Global Longitudinal Strain (GLS) in cardio-oncology.
  • To highlight the diagnostic and prognostic value of GLS in detecting early cardiotoxicity.
  • To guide clinicians on implementing strain imaging in clinical practice.

Main Methods:

  • Review of existing literature on GLS in cardio-oncology.
  • Inclusion of case studies with embedded videos demonstrating GLS acquisition and interpretation.
  • Discussion of practical implementation, training, and quality assurance for strain imaging.

Main Results:

  • Global Longitudinal Strain (GLS) is a sensitive marker for early cardiotoxicity.
  • GLS changes precede LVEF decline in patients undergoing cardiotoxic therapy.
  • GLS has established diagnostic and prognostic value in cardio-oncology.

Conclusions:

  • GLS is a crucial parameter for early detection and monitoring of cardiotoxicity.
  • The primer provides practical guidance for clinicians to integrate GLS into cardio-oncology practice.
  • Effective use of GLS can aid in guiding oncological therapy and optimizing patient care.