Functional role of miR‑155 in physiological and pathological processes of liver injury (Review)
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Published on: March 14, 2020
Xiao Feng1, Jiaying Bao2, Chunxia Song3
1Department of Gastroenterology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China.
Abstract:
There are several types of liver injury, including alcohol‑induced liver injury, drug‑induced liver injury, infectious liver injury, cirrhosis, liver ischemia/reperfusion injury and liver failure. In recent years, accumulated data have demonstrated that microRNAs (miRNAs/miRs) may be involved in the occurrence and development of a variety of systemic diseases, such as immune diseases, tumors and nervous system diseases. miR‑155 is a key miRNA, which has been studied extensively and has been shown to target different genes. In the present review, the potential effects and mechanisms of miR‑155 on the physiological and pathological processes of liver injury were reviewed from the perspective of cell stress, inflammation and activation of fibrosis. In addition, the potential benefits of miR‑155 as a therapeutic target and predictor of liver injury were summarized.
Insights
MicroRNAs (miRNAs) play a role in liver injury. This review focuses on microRNA-155 (miR-155) and its potential as a therapeutic target and predictor for various liver conditions.
Area of Science:
- Biomedical Science
- Molecular Biology
- Hepatology
Background:
- Liver injury encompasses diverse conditions like alcohol-induced injury, drug-induced liver injury, infections, cirrhosis, and ischemia/reperfusion.
- MicroRNAs (miRNAs) are increasingly recognized for their roles in systemic diseases, including immune disorders, tumors, and neurological conditions.
- MicroRNA-155 (miR-155) is a significant miRNA with established roles in targeting various genes.
Purpose of the Study:
- To review the potential effects and mechanisms of miR-155 in liver injury.
- To explore miR-155's involvement in cellular stress, inflammation, and fibrosis activation in the liver.
- To summarize the therapeutic potential and predictive value of miR-155 for liver injury.
Main Methods:
- Literature review of existing data on miRNAs and liver injury.
- Analysis of studies investigating miR-155's role in physiological and pathological liver processes.
- Synthesis of information regarding miR-155's impact on cell stress, inflammation, and fibrosis.
Main Results:
- miR-155 is implicated in the development and progression of liver injury.
- Mechanisms involve modulation of cell stress, inflammatory responses, and fibrotic activation.
- miR-155 influences key pathways relevant to liver pathology.
Conclusions:
- miR-155 is a critical regulator in liver injury.
- It presents potential as both a therapeutic target and a biomarker for liver disease.
- Further research into miR-155 mechanisms could lead to novel treatment strategies.
