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Gastrointestinal microbleeding after aspirin and naproxen.
Clinical Pharmacology and Therapeutics
|April 1, 1978
Summary
Naproxen may be a safer anti-inflammatory antirheumatic drug, causing less gastrointestinal blood loss than aspirin in rheumatoid arthritis patients. Further research is needed as the difference was not statistically significant.
Area of Science:
- Rheumatology
- Gastroenterology
- Pharmacology
Background:
- Gastrointestinal bleeding is a serious side effect of anti-inflammatory antirheumatic drugs.
- Previous studies compared blood loss with aspirin and naproxen in healthy volunteers.
Purpose of the Study:
- To compare gastrointestinal blood loss between naproxen and aspirin in rheumatoid arthritis patients.
- To evaluate the safety profile of naproxen in a patient population.
Main Methods:
- A double-blind, crossover study design was employed.
- 12 rheumatoid arthritis patients participated.
- The 51Cr labeling technique was used to quantify blood loss.
Main Results:
- A difference in blood loss was observed, favoring naproxen.
- The reduction in blood loss with naproxen compared to baseline was not statistically significant.
Conclusions:
- Naproxen demonstrated a potentially favorable gastrointestinal safety profile compared to aspirin in rheumatoid arthritis patients.
- Further investigation is warranted to confirm the statistical significance of these findings.