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Hyperhaemolytic transfusion reaction in two β-thalassaemia major patients: The role of eculizumab
Despoina Pantelidou1, Dimitrios Pilalas2, Stylianos Daios2
1Thalassaemia Unit, AHEPA University Hospital, Thessaloniki, Greece.
What Is Known And Objective:
Hyperhaemolytic transfusion reactions are rare life-threatening events predominantly affecting patients with haemoglobinopathies. We report two cases in β-thalassaemia major patients on chronic transfusion therapy and highlight the role of eculizumab in its management.
Case Summary:
Patient 1 presented with intravascular haemolysis on day 7 (D7) post-transfusion and responded to treatment with corticosteroids and intravenous immunoglobulin. However, patient 2 presented with severe symptomatic anaemia (D4 post-transfusion) unresponsive to the aforementioned measures. Eculizumab administration led to resolution of the hyperhaemolysis.
What Is New And Conclusion:
We report the successful management of hyperhaemolysis with eculizumab in a β-thalassemia major patient.
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