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Aberrant PTEN, PIK3CA, pMAPK, and TP53 expression in human scalp and face angiosarcoma

Huiying Wan1, Dingding Zhang2,3,4, Weimin Hu3

  • 1Department of Dermatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Medicine
|August 16, 2021
PubMed

Insights

This study reveals lower PTEN and higher PIK3CA, pMAPK, and TP53 expression in scalp and face angiosarcoma. These findings suggest PI3K, MAPK, and TP53 pathways are key in angiosarcoma development and potential therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pathology

Background:

  • Angiosarcoma is a rare, aggressive cancer originating from endothelial cells.
  • The molecular underpinnings of scalp and face angiosarcoma remain poorly understood.
  • Identifying key molecular pathways is crucial for targeted therapies.

Purpose of the Study:

  • To investigate the expression of PTEN, PIK3CA, pMAPK, and TP53 in scalp and face angiosarcoma.
  • To evaluate tumor tissue apoptosis in angiosarcoma.
  • To correlate protein expression with tumor differentiation.

Main Methods:

  • Immunohistochemistry was used to assess protein expression (PTEN, PIK3CA, pMAPK, TP53) in 21 angiosarcoma and 16 benign hemangioma specimens.
  • Terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) staining assessed tumor cell apoptosis.
  • Statistical analysis compared protein expression and apoptosis indices between angiosarcoma and benign tissues.

Main Results:

  • Angiosarcoma tissues showed significantly lower PTEN expression compared to benign hemangioma.
  • Higher expression of PIK3CA, pMAPK, and TP53 was observed in angiosarcoma.
  • Angiosarcoma tissues exhibited significantly higher apoptosis indices than benign hemangioma.
  • PIK3CA, pMAPK, and TP53 expression correlated with tumor differentiation.

Conclusions:

  • The PI3K, MAPK, and TP53 signaling pathways are implicated in the tumorigenesis of human scalp and face angiosarcoma.
  • Altered expression of PTEN, PIK3CA, pMAPK, and TP53 may contribute to angiosarcoma development.
  • These pathways represent potential therapeutic targets for angiosarcoma treatment.

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