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Cytomegalovirus infection in patients with glomerular diseases treated with cyclophosphamide: a single-center

Gizem Kumru Sahin1,2, Sahin Eyupoglu3, Rezzan Eren Sadioglu3

  • 1Department of Nephrology, Ankara University School of Medicine, Ankara, Turkey. gizemkumru@gmail.com.

International Urology and Nephrology
|August 16, 2021
PubMed
Abstract

Insights

Cytomegalovirus infection is common in glomerulonephritis patients on cyclophosphamide, occurring in 23.3%. Higher creatinine and lower eGFR were risk factors, suggesting monitoring is crucial for these patients.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Immunology

Background:

  • Cytomegalovirus (CMV) infection is a significant concern in immunocompromised individuals.
  • Cyclophosphamide treatment is a potential risk factor for CMV infection, particularly in patients with glomerulonephritis.

Purpose of the Study:

  • To determine the frequency of CMV infection in glomerulonephritis patients receiving cyclophosphamide.
  • To identify risk factors associated with CMV infection in this patient population.

Main Methods:

  • Prospective study of 43 CMV-seropositive glomerulonephritis patients treated with cyclophosphamide.
  • Monthly screening for CMV viral DNA during treatment.
  • Comparison of clinical and pathological factors between patients who developed CMV infection and those who did not.

Main Results:

  • CMV infection was detected in 23.3% of patients, primarily within two months of cyclophosphamide treatment.
  • Patients with CMV infection exhibited higher serum creatinine and lower estimated glomerular filtration rate (eGFR) at diagnosis.
  • Rapidly progressive glomerulonephritis and prolonged hospital stay were associated with CMV infection.

Conclusions:

  • CMV infection is a frequent complication in glomerulonephritis patients undergoing cyclophosphamide therapy.
  • Routine monitoring and prophylactic strategies are recommended for high-risk patients to mitigate CMV complications.
Keywords:
CyclophosphamideCytomegalovirusGlomerulonephritisImmunosuppressive treatment

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