Does the TMPRSS6 C > T Polymorphism Modify the Endurance Training Effects on Hematological Parameters?

Area of Science:

• Sports Medicine
• Genetics
• Hematology

Background:

• The TMPRSS6 C>T polymorphism (TMPRP) role in aerobic training's hematological effects is largely unknown.
• Soccer referees, undergoing chronic aerobic training, present a unique population for studying these effects.

Purpose of the Study:

• To investigate the influence of TMPRP on hematological parameters after chronic aerobic training in male soccer referees.
• To compare hematological profiles between athletic and sedentary groups with different TMPRP genotypes.

Main Methods:

• Comparison of hemogram, serum hepcidin, ferritin, and iron levels between athletic (n=45) and sedentary (n=42) male groups.
• Determination of TMPRP genotype from DNA samples and assessment of physical/physiological parameters (e.g., Yo-Yo test).

Main Results:

• Athletic T carriers (Tc) showed significantly higher RBC counts than controls (p<0.01).
• Athletic CC homozygotes had lower serum iron and transferrin saturation (TS) compared to controls.
• Training did not alter hepcidin levels; however, TMPRP influenced iron, TS, and RBC count responses to training.

Conclusions:

• TMPRP genotype significantly modifies the hematological response to endurance training.
• The CC genotype may be susceptible to adverse effects on iron and TS levels from endurance training.
• Personalized training programs considering individual phenotype characteristics are recommended.