Related Experiment Video
Updated: Oct 24, 2025
09:02
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
21.7K
Genetics of Chronic Lymphocytic Leukemia
Francesc Bosch, Riccardo Dalla-Favera1
1Institute for Cancer Genetics, Columbia University, New York, NY.
Cancer Journal (Sudbury, Mass.)
|August 16, 2021
Summary
Recent advances in analyzing the genome, epigenome, and transcriptome of chronic lymphocytic leukemia (CLL) have improved understanding of its pathogenesis and evolution. This includes insights into chemotherapy resistance and responses to targeted therapies.
Area of Science:
- Hematology
- Oncology
- Genomics
Background:
- Chronic lymphocytic leukemia (CLL) pathogenesis understanding has advanced.
- Integrated genomic, epigenomic, and transcriptomic analyses are key.
Purpose of the Study:
- To review the current understanding of CLL pathogenesis.
- To highlight genetic heterogeneity and altered biological pathways in CLL.
Main Methods:
- Integrated analysis of genome, epigenome, and transcriptome.
- Review of current literature on CLL genetic lesions.
Main Results:
- Advances in understanding CLL initiation and evolution.
- Insights into chemoresistance and targeted therapy sensitivity/resistance.
Conclusions:
- Genetic heterogeneity significantly impacts CLL.
- Altered biological pathways are central to CLL development and treatment response.
More Related Videos
Related Concept Videos
01:21Lineage Commitment
3.6K
Commitment is the process whereby stem cells:
3.6K
01:27Disorders of Leukocytes
1.3K
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
1.3K
03:18Non-LTR Retrotransposons
12.2K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.2K
01:18Lymphoid Cells and Tissues
2.0K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
2.0K
01:16Primary Lymphoid Organs
11.9K
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
11.9K