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Periodic Catatonia: Long-term Treatment With Lamotrigine: A Case Report
Journal of Psychiatric Practice
|August 16, 2021
Summary
Periodic catatonia, a rare cyclic disorder, presents urgent management challenges. Long-term lamotrigine treatment may prevent recurrent episodes, offering a potential prophylactic strategy for this condition.
Area of Science:
- Psychiatry
- Neurology
Background:
- Periodic catatonia is a rare cyclic disorder characterized by episodes of stupor and excitement with remissions.
- Its pathophysiology remains unclear, complicating management and prevention strategies.
Observation:
- This case study details a patient with periodic catatonia.
- The patient received long-term treatment with lamotrigine.
Findings:
- Lamotrigine treatment appeared to prophylactically reduce the occurrence and severity of recurrent catatonic episodes.
- This suggests a potential role for lamotrigine in preventing future episodes.
Implications:
- Further research into periodic catatonia pathophysiology is needed.
- Increased physician awareness of periodic catatonia presentation is beneficial.
- Lamotrigine shows promise as a prophylactic treatment, warranting further clinical investigation.

