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Updated: Oct 23, 2025

Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish
06:46

Accumulation and Distribution of Fluorescent Microplastics in the Early Life Stages of Zebrafish

Published on: July 4, 2021

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Microplastics induced developmental toxicity with microcirculation dysfunction in zebrafish embryos.

Sung Ho Park1, Kiwoong Kim2

  • 1Mechanical Engineering, Pohang University of Science and Technology, Pohang, 37673, South Korea.

Chemosphere
|August 16, 2021
PubMed
Summary
This summary is machine-generated.

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Microplastics (MPs) and nanoplastics (NPs) cause zebrafish embryo developmental disorders. Exposure to these plastic particles impairs growth and peripheral microcirculation, highlighting environmental risks.

Area of Science:

  • Environmental Science
  • Toxicology
  • Developmental Biology

Background:

  • Microplastics (MPs) and nanoplastics (NPs) are emerging environmental pollutants.
  • Limited data exists on their toxic effects during organismal development.

Purpose of the Study:

  • To evaluate the toxic effects of MPs (1 μm) and NPs (0.4 μm) on zebrafish embryos.
  • To investigate the impact on mortality, growth, and microcirculation.

Main Methods:

  • Zebrafish embryos were exposed to MPs and NPs at early developmental stages.
  • Mortality rates, pathological changes, and caudal microcirculation were assessed.

Main Results:

  • NPs induced higher mortality than MPs at equivalent mass concentrations.
Keywords:
DysfunctionEmbryosMicroirculationMicroplasticsZebrafish

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  • Both MPs and NPs caused pathological changes in the caudal vein plexus and impaired growth.
  • Peripheral microcirculation in the caudal region was significantly deteriorated, though systemic perfusion was maintained.

    • Conclusions:

    • Exposure to MPs and NPs can lead to developmental disorders in zebrafish embryos.
    • Plastic particle exposure impairs embryonic growth and causes peripheral microcirculation dysfunction.
    • This study offers insights into the developmental toxicity of plastics.