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Cancer-fighting potentials of algal polysaccharides as nutraceuticals

Yuezhen Ouyang1, Yinghui Qiu1, Yuning Liu1

  • 1Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou, China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Food Research International (Ottawa, Ont.)
|August 17, 2021
PubMed

Insights

Algal polysaccharides show potent anticancer properties by inducing apoptosis and regulating immune function. They offer a promising avenue for cancer treatment, potentially reducing side effects when combined with other therapies.

Area of Science:

  • Marine Biology
  • Biochemistry
  • Immunology

Background:

  • Cancer remains a leading cause of death globally, with current treatments often limited by efficacy and severe side effects.
  • Algae are recognized for their nutritional value and possess bioactive compounds, notably polysaccharides with significant anticancer and immunomodulatory potential.

Purpose of the Study:

  • To review the anticancer mechanisms of algal polysaccharides.
  • To explore their role in modulating the immune system and intestinal flora.
  • To discuss the application of nanoparticles and combination therapies involving algal polysaccharides for cancer treatment.

Main Methods:

  • Literature review of scientific studies on algal polysaccharides and cancer.
  • Analysis of signal pathways involved in anticancer effects.
  • Examination of studies on nanoparticle-drug delivery systems and combination therapies.

Main Results:

  • Algal polysaccharides exhibit anticancer activities through apoptosis induction, cell cycle arrest, and anti-angiogenesis.
  • These compounds modulate intestinal flora and enhance immune function, contributing to their therapeutic effects.
  • Combination strategies with nanoparticles and other drugs can mitigate chemotherapy side effects and potentiate anticancer efficacy.

Conclusions:

  • Algal polysaccharides represent a promising source of novel anticancer agents.
  • Further research into their mechanisms and clinical applications, including combination therapies, is warranted.
  • The integration of nanotechnology and understanding of host-microbiome interactions can optimize their therapeutic potential.
Keywords:
Algal polysaccharidesAnti-cancerGut microbiota: Immune regulation

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