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Updated: Oct 23, 2025

Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
Long-term antimicrobial effectiveness of a silver-impregnated foil on high-touch hospital surfaces in patient rooms
Andreas F Widmer1, Sonja Kuster2,3, Marc Dangel2
1Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, 4031, Basel, Switzerland. andreas.widmer@usb.ch.
Background:
The hospital environment has got more attention as evidence as source for bacterial transmission and subsequent hospital-acquired infection increased. Regular cleaning and disinfection have been proposed to lower the risk of infection, in particular for gram-positive bacteria. Auto-disinfecting surfaces would allow to decrease survival of pathogens, while limiting resource to achieve a safe environment in patient rooms.
Methods:
A controlled trial to evaluate the antimicrobial effectiveness of a polyvinyl chloride foil containing an integrated silver-based agent (containing silver ions 2%) on high-touch surfaces in patient rooms.
Results:
The overall log reduction of the mean values was 1.8 log10 CFU, the median 0.5 log10 CFU comparing bioburden of control vs antimicrobial foil (p < 0.01). Important pathogens were significantly less likely recovered from the foil, in particular enterococci. These effects were present even after 6 months of in-use.
Conclusions:
A foil containing an integrated silver-based agent applied to high-touch surfaces effectively results in lower recovery of important pathogens from such surfaces over a 6-month study period.
Insights
Antimicrobial foil with silver ions significantly reduced bacterial contamination on hospital surfaces. This auto-disinfecting surface technology offers a promising approach to enhance patient room safety and reduce hospital-acquired infections.
Area of Science:
- Infection control
- Materials science
- Microbiology
Background:
- Hospital environments are recognized as significant sources of bacterial transmission and hospital-acquired infections.
- Conventional cleaning and disinfection methods aim to reduce infection risks, particularly from gram-positive bacteria.
- Auto-disinfecting surfaces present a novel strategy to limit pathogen survival and maintain safe patient room environments.
Purpose of the Study:
- To evaluate the antimicrobial efficacy of a polyvinyl chloride (PVC) foil integrated with a silver-based agent.
- To assess the effectiveness of this antimicrobial foil on high-touch surfaces within patient rooms.
Main Methods:
- A controlled trial was conducted to assess the antimicrobial properties of the PVC foil.
- The foil contained a silver-based agent with 2% silver ions.
- Its application was on high-touch surfaces in patient rooms, with bioburden compared to control surfaces.
Main Results:
- A significant reduction in the overall mean bacterial load was observed (1.8 log10 CFU), with a median reduction of 0.5 log10 CFU (p < 0.01).
- Key pathogens, notably enterococci, were recovered less frequently from the antimicrobial foil surfaces.
- These antimicrobial effects persisted effectively for up to 6 months of use.
Conclusions:
- The integrated silver-based agent within the PVC foil demonstrates effective antimicrobial properties on high-touch surfaces.
- Application of this foil significantly reduces the recovery of critical pathogens over a 6-month period.
- This technology offers a sustainable solution for enhancing environmental hygiene and reducing infection transmission in healthcare settings.
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