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Cardiac Reverse Remodeling After Transcatheter Patent Ductus Arteriosus Closure in Adults

Zahra Khajali1, Ata Firouzi2, Farshad Shakerian2

  • 1Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Current Problems in Cardiology
|August 17, 2021
PubMed

Insights

Percutaneous closure of patent ductus arteriosus (PDA) in adults shows promising cardiac improvements. This study evaluated long-term outcomes, comparing adult results to pediatric data for transcatheter closure (TCC) of PDA.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Pediatric Cardiology

Background:

  • Patent ductus arteriosus (PDA) is commonly treated in childhood with excellent outcomes.
  • Long-term results of percutaneous PDA closure in adults remain less understood.
  • Positive cardiac reverse remodeling is well-documented in pediatric PDA patients.

Purpose of the Study:

  • To evaluate the long-term outcomes (at least 1-year follow-up) of transcatheter closure (TCC) for patent ductus arteriosus (PDA) in adult patients.
  • To compare hemodynamic and cardiac reverse remodeling findings in adults post-TCC with existing pediatric and adult data.
  • To assess the comprehensibility of percutaneous PDA closure outcomes in the adult population.

Main Methods:

  • Retrospective cohort study design.
  • Inclusion of 121 adult patients (age >16 years) undergoing TCC for PDA between 2012 and 2018.
  • Minimum 1-year follow-up for all included patients.

Main Results:

  • (Results not detailed in the abstract, but would typically include hemodynamic changes and degree of cardiac reverse remodeling.)
  • Comparison of adult TCC outcomes against established pediatric benchmarks.
  • Assessment of the clinical significance of TCC in adult PDA management.

Conclusions:

  • Transcatheter closure of PDA in adults warrants further investigation for long-term efficacy.
  • Understanding adult outcomes is crucial for comprehensive PDA management guidelines.
  • Potential for positive cardiac remodeling in adults following PDA closure, comparable to pediatric populations.

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