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Updated: Oct 23, 2025

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
Published on: August 11, 2023
Extraosseous odontogenic fibroma with a clear cells component: a 5-year follow-up
Estefanía Retama-Carranza1, Miguel Padilla-Rosas1, José Sergio Zepeda-Nuño2
1Master's Program in Oral Pathology and Medicine, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, México.
Abstract:
The extraosseous/peripheral odontogenic fibroma (E/POF) is a benign mesenchymal odontogenic tumour found on the gingival surface with clinical characteristics identical to those of reactive lesions. A histopathological analysis is the only method for determining the difference between reactive lesions and these neoplastic lesions, whose recurrence potential varies between 38.9% and 50%, highlighting the importance of correct diagnosis. The following report describes an E/POF case with a clear cells component, as well as a long-term follow-up treatment, which we emphasise due to its potential for recurrence.

