Related Experiment Video
Updated: Oct 23, 2025

04:25
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
10.3K
Primary leiomyosarcoma of the distal tibia: A case report
Sachin Dheer1, Pamela Gekas2, Faith Schick2
1Department of Radiology, Thomas Jefferson University, 111 South 10 Street, Philadelphia, PA 19103.
Radiology Case Reports
|August 17, 2021
Summary
This case report details a rare leiomyosarcoma in the distal tibia bone. Definitive diagnosis required biopsy and immunochemistry due to non-specific imaging findings.
Area of Science:
- Oncology
- Orthopedic Surgery
- Pathology
Background:
- Leiomyosarcoma typically originates in smooth muscle tissues.
- Primary bone leiomyosarcoma is exceptionally rare.
- Lower limb bone involvement is even rarer.
Observation:
- A case of leiomyosarcoma in the distal tibia is presented.
- Plain film radiographs and MRI showed nonspecific findings.
- Biopsy with immunochemistry staining was crucial for diagnosis.
Findings:
- The tumor was identified as a leiomyosarcoma.
- Immunochemistry confirmed the diagnosis.
- The lesion was lytic and intramedullary.
Implications:
- This rare bone tumor should be considered in the differential diagnosis of lytic bone lesions.
- Timely and thorough evaluation of aggressive-appearing bone lesions is essential.
- Highlights the importance of biopsy and immunochemistry for definitive diagnosis of rare bone tumors.

