Related Experiment Video

Updated: Oct 23, 2025

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

14.8K

Hyperlipidemia: A Review of the Novel Methods for the Management of Lipids

Kosisochukwu J Ezeh1, Obiora Ezeudemba2

  • 1Internal Medicine, Jersey City Medical Center, Jersey City, USA.

Cureus
|August 17, 2021
PubMed

Insights

Hyperlipidemia, a common cause of cardiovascular disease, is linked to cholesterol levels. Lowering low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL) can reduce adverse events.

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Lipidology

Background:

  • Hyperlipidemia is a primary modifiable risk factor for atherosclerotic cardiovascular disease (ASCVD).
  • A strong inverse correlation exists between lipid levels, specifically low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL), and the occurrence of major adverse cardiovascular events (MACE).
  • Understanding lipid metabolism is crucial for managing cardiovascular risk.

Purpose of the Study:

  • To provide a comprehensive overview of lipid metabolism.
  • To discuss the pathophysiology and clinical significance of hyperlipidemia.
  • To review current and emerging strategies for hyperlipidemia management.

Main Methods:

  • Literature review of scientific articles and clinical guidelines.
  • Synthesis of information on lipid biochemistry and pathophysiology.
  • Analysis of evidence-based approaches to hyperlipidemia treatment.

Main Results:

  • Lipids, including cholesterol and triglycerides, play a vital role in cellular function and cardiovascular health.
  • Elevated levels of LDL-C and non-HDL cholesterol are directly associated with increased ASCVD risk.
  • Effective management strategies aim to reduce atherogenic lipoproteins to mitigate cardiovascular events.

Conclusions:

  • Hyperlipidemia management is a cornerstone of cardiovascular disease prevention.
  • Targeting LDL-C and non-HDL cholesterol is essential for reducing MACE.
  • A thorough understanding of lipid metabolism informs optimal therapeutic interventions.

Keywords:
bempedoic acidezetimibeldl-clipid metabolismlow density lipoprotein-cholesterolniacinpcsk-9 inhibitorstatin-induced myopathy

More Related Videos

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs08:18

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

1.3K
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.3K

Related Concept Videos

Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
993
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
75
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
3.2K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
588
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
68
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
29