Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

119
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
119
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

99
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
99
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

85
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
85
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

95
Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
95
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

2.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
2.0K
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

125
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
125

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ProtekDuo Cannulation via Right External Jugular Vein: A First in Man Method Description.

Annals of cardiac anaesthesia·2026
Same author

The United States Experience With Combined Lung+Liver Transplantation.

Annals of thoracic surgery short reports·2026
Same author

Survival With β-Adrenergic Suppression After Lung Transplantation.

Journal of the American Heart Association·2026
Same author

Alpha-2 antiplasmin deficiency: a rare fibrinolytic disorder identified after decades of diagnostic delay.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2026
Same author

A Perspective Summary of the ISHLT Consensus Statement on Acute Lung Allograft Dysfunction (ALAD).

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

ISHLT Consensus Statement on Acute Lung Allograft Dysfunction (ALAD): Definition, Etiology, Diagnostic and Therapeutic Approaches, and Research Priorities.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026

Related Experiment Video

Updated: Oct 23, 2025

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

939

Macrophage activating syndrome causing decompensated right heart failure.

Mwelwa Chizinga1, Saminder Singh Kalra1, Ayoub Innabi1

  • 1University of Florida, Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, Gainesville, FL, USA.

Respiratory Medicine Case Reports
|August 17, 2021
PubMed
Summary

Macrophage activating syndrome (MAS) can cause severe pulmonary arterial hypertension and right heart failure. Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) offers a bridge to recovery in refractory cases, as demonstrated in this adult patient.

Keywords:
HyperferritenemiaMacrophage activation syndromePulmonary arterial hypertensionRight heart failureSystemic juvenile idiopathic arthritis

More Related Videos

Culture of Macrophage Colony-stimulating Factor Differentiated Human Monocyte-derived Macrophages
06:46

Culture of Macrophage Colony-stimulating Factor Differentiated Human Monocyte-derived Macrophages

Published on: June 30, 2016

30.1K
Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry
07:14

Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry

Published on: October 18, 2016

15.0K

Related Experiment Videos

Last Updated: Oct 23, 2025

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

939
Culture of Macrophage Colony-stimulating Factor Differentiated Human Monocyte-derived Macrophages
06:46

Culture of Macrophage Colony-stimulating Factor Differentiated Human Monocyte-derived Macrophages

Published on: June 30, 2016

30.1K
Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry
07:14

Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry

Published on: October 18, 2016

15.0K

Area of Science:

  • Cardiology
  • Rheumatology
  • Critical Care Medicine

Background:

  • Macrophage activating syndrome (MAS) is a life-threatening hemophagocytic lymphohistiocytosis (HLH) complication of autoimmune diseases.
  • MAS triggers cytokine storm and multiorgan failure, including cardiovascular compromise.

Observation:

  • A 32-year-old male with MAS developed acutely decompensated pulmonary arterial hypertension (PAH) and right heart failure.
  • Conventional therapies including epoprostenol and vasopressors were ineffective, necessitating veno-arterial extracorporeal membrane oxygenation (VA-ECMO).

Findings:

  • MAS precipitated refractory right heart failure, requiring VA-ECMO as a bridge to recovery.
  • Early immunosuppression with anakinra and dexamethasone was crucial for managing MAS.
  • Successful VA-ECMO decannulation and transition to oral treprostinil were achieved.

Implications:

  • This case highlights VA-ECMO's utility in managing adult MAS-induced refractory right heart failure.
  • Early consideration of VA-ECMO and immunosuppressants is vital for severe MAS cases.
  • Further research is needed to support VA-ECMO use in adult MAS patients.